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The current League leaders Liverpool travel to the south coast without a number of key men. Both full backs, Trent Alexander-Arnold and Andy Robertson are injured, as are Thiago and Joel Matip, while Wataru Endo and Mohamed Salah are away on international duty for the foreseeable future.
And now that could mean another start at full back for Conor Bradley, who filled in at right back in their EFL Cup win over Fulham.
Also the Reds won 2-1 at the Vitality in the Carabao Cup earlier this season, Cody Gakpo and Darwin Nunez scoring, and they will take confidence from that.
Therefore with Manchester City now breathing down their neck in the league, the visitors cannot afford to slip up and drop points here.